Watkins K L, Bafundo K W, Donovan D J
Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana 46140.
Poult Sci. 1990 Jun;69(6):1009-11. doi: 10.3382/ps.0691009.
Four chick and five poult trials were conducted in order to investigate the anticoccidial efficacy of monensin against Eimeria mitis in chickens and Eimeria dispersa in turkeys. The chicks were fed a basal diet with either 0 or 100 ppm of monensin. The poults were fed a basal diet with either 0 or 60 ppm of monensin. Two days after the initiation of each experiment, the chicks and poults were crop-intubated with oocysts of E. mitis and E. dispersa, respectively. A group was also included that was not infected and not medicated. Growth and feed intake were recorded. At 6 or 7 days postinoculation, the birds were killed by cervical dislocation and were scored for the incidence and severity of intestinal abnormalities. The Eimeria mitis infection reduced (P less than .01) gain and the feed:gain ratio, compared with uninfected birds; the E. dispersa infection only reduced (P less than .05) gain. Although well-defined, discrete lesions were not observed, marked intestinal abnormalities were noted in birds infected with either E. mitis or E. dispersa. Also, the infected, unmedicated birds had increased (P less than .01) intestinal scores compared with uninfected birds or those with infection but treated with monensin. Monensin eliminated the reduction in gain and feed efficiency seen in the infected birds. The infected birds fed monensin had intestinal scores, gain, and feed:gain ratios similar (P greater than .10) to those for the birds that were not infected and that did not receive medication.
进行了四项雏鸡试验和五项幼火鸡试验，以研究莫能菌素对鸡的微小艾美耳球虫和火鸡的分散艾美耳球虫的抗球虫效果。给雏鸡饲喂含0或100 ppm莫能菌素的基础日粮。给幼火鸡饲喂含0或60 ppm莫能菌素的基础日粮。在每项试验开始两天后，分别给雏鸡和幼火鸡嗉囊接种微小艾美耳球虫和分散艾美耳球虫的卵囊。还设置了一组未感染且未用药的对照。记录生长情况和采食量。接种后6或7天，通过颈椎脱臼法处死鸡，并对肠道异常的发生率和严重程度进行评分。与未感染的鸡相比，感染微小艾美耳球虫降低了（P＜0.01）增重和料重比；感染分散艾美耳球虫仅降低了（P＜0.05）增重。虽然未观察到明确、离散的病变，但感染微小艾美耳球虫或分散艾美耳球虫的鸡出现了明显的肠道异常。此外，与未感染的鸡或感染但用莫能菌素治疗的鸡相比，感染且未用药的鸡肠道评分增加（P＜0.01）。莫能菌素消除了感染鸡增重和饲料效率的降低。饲喂莫能菌素的感染鸡的肠道评分、增重和料重比与未感染且未用药的鸡相似（P＞0.10）。
