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超声促进的绿色方法,使用天然、稳定和可重复使用的斜发沸石纳米沸石催化剂,在室温下合成磺胺类药物。

Ultrasound-promoted green approach for the synthesis of sulfonamides using natural, stable and reusable Natrolite nanozeolite catalyst at room temperature.

机构信息

Department of Chemistry, Faculty of Science, University of Qom, Qom 37185-359, Iran.

出版信息

Ultrason Sonochem. 2014 Jan;21(1):275-82. doi: 10.1016/j.ultsonch.2013.07.012. Epub 2013 Jul 30.

DOI:10.1016/j.ultsonch.2013.07.012
PMID:23958356
Abstract

Natural Natrolite nanozeolite has been investigated as an efficient and reusable catalyst for the N-sulfonylation of amines under ultrasound irradiation at room temperature. Compared with traditional methods, the significant advantages for method are green solvent, milder and cleaner conditions, higher purity and yields, shorter reaction time, easier work-up procedure and the lower generation of waste or pollutions. The catalyst can be recovered and reused several times without significant loss of its catalytic activity.

摘要

天然钠沸石纳米沸石已被研究作为一种高效且可重复使用的催化剂,用于在室温下超声辐射下胺的 N-磺酰化反应。与传统方法相比,该方法具有绿色溶剂、更温和、更清洁的条件、更高的纯度和收率、更短的反应时间、更简单的后处理步骤以及产生的废物或污染物更少等显著优点。催化剂可以回收并重复使用多次,而其催化活性没有明显损失。

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