内抑素水平与子痫前期发生风险的关系。

Endostatin levels and the risk of subsequent preeclampsia.

机构信息

Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, 3175 Cote Ste-Catherine, Montreal, Quebec H3T 1C5, Canada.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2013 Oct;170(2):396-400. doi: 10.1016/j.ejogrb.2013.07.039. Epub 2013 Aug 7.

DOI:10.1016/j.ejogrb.2013.07.039

PMID:23958573

Abstract

OBJECTIVE

To evaluate endostatin, an anti-angiogenic factor, in relation to the risk of preeclampsia (PE).

STUDY DESIGN

In this case control study, serum samples were collected at 11-17 weeks and 18-26 weeks' gestation. Endostatin levels were expressed as adjusted multiples of the median (MoM). Logistic regression was used to calculate adjusted odds ratios (aORs) for the prediction of PE.

RESULTS

A total of 77 women with PE and 150 controls were studied. Endostatin levels were significantly higher in women with PE compared to controls in both the first and the second trimester. At a cut-off level of 75th percentile of endostatin MoMs, the aORs for PE were 1.33 (95% confidence interval [CI], 0.68-2.58) at 11-17 weeks and 1.77 (95% CI, 0.94-3.34) at 18-26 weeks, after adjustment for ethnicity and chronic hypertension. The aORs for early-onset PE were 3.51 (95% CI, 1.18-10.43) at 11-17 weeks and 2.17 (95% CI, 0.67-7.06) at 18-26 weeks.

CONCLUSIONS

Higher endostatin levels are associated with an increased risk of early onset PE. Endostatin alone, however, has a poor predictive value for clinical usefulness.

摘要

目的

评估血管生成抑制因子内皮抑素与子痫前期（PE）风险的关系。

研究设计

在这项病例对照研究中，于 11-17 周和 18-26 周妊娠时采集血清样本。将内皮抑素水平表示为中位数（MoM）的调整倍数。使用逻辑回归计算内皮抑素预测 PE 的调整比值比（aOR）。

结果

共研究了 77 例 PE 妇女和 150 例对照者。与对照组相比，PE 妇女在第一和第二孕期的内皮抑素水平均显著升高。在内皮抑素 MoM 的 75 百分位数截断值处，11-17 周和 18-26 周时，PE 的 aOR 分别为 1.33（95%置信区间 [CI]，0.68-2.58）和 1.77（95% CI，0.94-3.34），调整种族和慢性高血压后。11-17 周时早发型 PE 的 aOR 为 3.51（95% CI，1.18-10.43），18-26 周时为 2.17（95% CI，0.67-7.06）。