Morin R J, Willoughby D
Am J Clin Pathol. 1975 Aug;64(2):241-7. doi: 10.1093/ajcp/64.2.241.
Activated partial thromboplastin times (APTT's) performed with a semi-automated electrical-conductivity type of clot timer on plasmas from patients with hepatic disease and intravascular coagulation, and on warfarin or heparin therapy, were significantly lower than when done on the same plasmas with either a manual optical method or an automated optical-endpoint instrument. Results of APTT's done on normal plasmas by the three methods were not significantly different. Substitution of different activator-phospholipid reagents resulted in some variability in results, but these differences were less than those between the different done with both the electrical clot timer and the automated optical instrument on prepared plasmas containing 5.0 or 1.0% of factor II, V, VIII, IX, OR X revealed shorter times with the electrical clot timer only in the case of factor II- and factor V-deficient plasmas. APTT's done on normal plasmas to which 0.1 or 0.3 units per ml. of heparin had been added vitro also were shorter with the electrical clot itmer than the automatic optical instrument. Prothrombin times done on normal and abnormal control plasmas and on a series of plasmas from patients on warfarin therapy showed no significant difference between the two methods.
使用半自动电导率型凝血时间测定仪对患有肝脏疾病和血管内凝血的患者血浆以及接受华法林或肝素治疗的患者血浆进行活化部分凝血活酶时间（APTT）检测时，其结果显著低于使用手动光学方法或自动光学终点仪器对相同血浆进行检测的结果。用这三种方法对正常血浆进行APTT检测的结果无显著差异。更换不同的激活剂 - 磷脂试剂会导致结果出现一些变化，但这些差异小于使用电凝时间测定仪和自动光学仪器对含有5.0%或1.0%的因子II、V、VIII、IX或X的制备血浆进行检测时的差异，仅在因子II和因子V缺乏的血浆中，电凝时间测定仪显示的时间较短。在体外添加了每毫升0.1或0.3单位肝素的正常血浆上进行的APTT检测，电凝时间测定仪检测出的时间也比自动光学仪器检测出的时间短。对正常和异常对照血浆以及一系列接受华法林治疗患者的血浆进行凝血酶原时间检测时，两种方法之间无显著差异。
