Hagen V, Klauschenz E, Rumler A, Niedrich H, Hagen A, Heer S, Mitzner R
Akademie der Wissenschaften der DDR.
Pharmazie. 1990 May;45(5):343-5.
By acylation of our previously described cardiotonic active 2-hydroxyalkylamino, 2-hydroxyalkoxy, 2-aminoalkyl-amino and 2-piperazino substituted 3-cyano-5-(4-pyridinyl) pyridines with acetic anhydride, propionic anhydride or aroyl and heteroaroyl chlorides, respectively, the corresponding in position 2 O- or N-acylated 3-cyano-5-(4-pyridinyl)pyridines were prepared. Cardiovascular activity of the obtained derivatives is discussed in comparison with that of the parent compounds.
通过分别用乙酸酐、丙酸酐或芳酰氯和杂芳酰氯酰化我们之前描述的具有强心活性的2-羟烷基氨基、2-羟烷氧基、2-氨基烷基氨基和2-哌嗪基取代的3-氰基-5-(4-吡啶基)吡啶，制备了相应的在2位O-或N-酰化的3-氰基-5-(4-吡啶基)吡啶。将所得衍生物的心血管活性与母体化合物的心血管活性进行了比较讨论。
