Key Lab of Food Safety Risk Assessment, Ministry of Health and China Center for Food Safety Risk Assessment, 29 Nanwei Road, Beijing 100050, PR China; Suzhou Center for Disease Control and Prevention, Sanxiang Road 72, Suzhou 215004, Jiangsu Province, PR China.
Sci Total Environ. 2014 Jan 1;466-467:609-15. doi: 10.1016/j.scitotenv.2013.07.008. Epub 2013 Aug 19.
This study was conducted to determine the human body burden of polybrominated diphenyl ethers (PBDEs) and then clarify the relationships between that and the disruption of thyroid hormones in the general population in Northern China. Between November 2010 and May 2011, 124 serum samples were obtained from volunteers from the provinces of Shanxi and Liaoning. Serum samples were prepared by solid-phase extraction and analyzed for BDE-17, 28, 47, 66, 99, 100, 153, 154, 183 and 209 by gas chromatography-negative chemical ionization mass spectrometry. The median concentration of the total PBDEs was 7.2 ng/g lipid weights (lw); concentrations ranged from 2.1 to 160.3 ng/glw. The PBDE profiles in this study differed from those of other general populations. BDE-209 was the most abundant congener (median, 5.0 ng/glw; range, non-detected - 157.1 ng/glw), accounting for more than 75% of the total PBDEs, followed by BDE-153. The total PBDE concentrations in men were significantly higher as compared to women. The donors' age was correlated with a few PBDE congeners, but was not correlated with the total PBDE concentrations. The overall level of PBDEs in this study was lower than that observed in general populations in Southern China, Europe, and North America. There were apparent correlations between concentrations of several PBDE congeners and thyroid hormones. Triiodothyronine (T₃) was correlated with BDE-99 and 209 and inversely correlated with BDE-17, 28, 47, 153, 183, and the summed tri- to hepta-PBDE congeners (∑₃₋₇PBDEs). Thyroid-stimulating hormone (TSH) was correlated with BDE-17, 28, 47, and 183 and inversely correlated with BDE-99. No correlation between free tetraidothyronine (FT₄) and PBDEs was observed. Logistic regression analysis results indicated that those with higher levels of BDE-17 or BDE-153 had significantly lower odds of having T₃ levels above the normal range compared to those with lower levels of BDE-17 or BDE-153. Association between FT₄ and BDE-153 disappeared after controlling for sex and age. However, there was no significant association between TSH and PBDEs. The results of the present study showed that even at a relatively low level, PBDEs might interfere with the thyroid hormone levels in the general population.
本研究旨在确定人体内多溴二苯醚（PBDEs）的含量，然后阐明其与中国北方普通人群甲状腺激素紊乱之间的关系。2010 年 11 月至 2011 年 5 月，从山西省和辽宁省的志愿者中采集了 124 份血清样本。通过固相萃取法制备血清样本，并通过气相色谱-负化学电离质谱法分析 BDE-17、28、47、66、99、100、153、154、183 和 209。总 PBDEs 的中位数浓度为 7.2ng/g 脂质重量（lw）；浓度范围为 2.1 至 160.3ng/glw。本研究中的 PBDE 分布与其他普通人群不同。BDE-209 是最丰富的同系物（中位数为 5.0ng/glw；范围，未检出-157.1ng/glw），占总 PBDEs 的 75%以上，其次是 BDE-153。男性的总 PBDE 浓度明显高于女性。供体的年龄与一些 PBDE 同系物有关，但与总 PBDE 浓度无关。与中国南方、欧洲和北美的普通人群相比，本研究中的 PBDE 总体水平较低。几种 PBDE 同系物的浓度与甲状腺激素之间存在明显的相关性。三碘甲状腺原氨酸（T₃）与 BDE-99 和 209 呈正相关，与 BDE-17、28、47、153、183 和总和七溴二苯醚同系物（∑₃₋₇PBDEs）呈负相关。促甲状腺激素（TSH）与 BDE-17、28、47 和 183 呈正相关，与 BDE-99 呈负相关。未观察到游离四碘甲状腺原氨酸（FT₄）与 PBDEs 之间存在相关性。逻辑回归分析结果表明，与低水平 BDE-17 或 BDE-153 相比，高水平 BDE-17 或 BDE-153 的个体 T₃ 水平处于正常范围的可能性显著降低。在控制性别和年龄后，FT₄ 与 BDE-153 之间的关联消失。然而，TSH 与 PBDEs 之间无显著相关性。本研究结果表明，即使在相对较低的水平，PBDEs 也可能干扰普通人群的甲状腺激素水平。
