Rose J D
Department of Psychology, University of Wyoming, Laramie 82071.
Physiol Behav. 1990 Jun;47(6):1201-12. doi: 10.1016/0031-9384(90)90373-c.
The hypothalamus is known to be critical for the neuroendocrine control of sexual behavior, but the neural effects of gonadal hormones on behavior-related activity of hypothalamic neurons has received little investigation. The present study examined the effects on single hypothalamic neurons of lordosis-inducing estrogen and progesterone administration to behaving golden hamsters. The lordosis-inducing action of the hormones was associated with rapidly emerging, cumulative changes in the activity level and somatosensory responsiveness of neurons throughout the hypothalamus, as well as the appearance in most neurons of lordosis-correlated firing. This functional reconfiguration of hypothalamic neuronal properties resembled, in time course and other aspects, effects of estrogen and progesterone previously observed in hamster midbrain neurons. Although the firing rates of the hypothalamic neurons were typically low, the lordosis-related activity of these neurons was compatible with a role in the control of individual episodes of lordosis as well as a state-related tendency to exhibit the lordosis response.
已知下丘脑对性行为的神经内分泌控制至关重要，但性腺激素对下丘脑神经元行为相关活动的神经影响却鲜有研究。本研究检测了对正在表现出脊柱前凸行为的金黄地鼠给予诱导脊柱前凸的雌激素和孕酮后，对单个下丘脑神经元的影响。激素诱导脊柱前凸的作用与整个下丘脑神经元活动水平和体感反应性迅速出现的累积变化相关，以及大多数神经元出现与脊柱前凸相关的放电。下丘脑神经元特性的这种功能重构在时间进程和其他方面类似于先前在仓鼠中脑神经元中观察到的雌激素和孕酮的作用。尽管下丘脑神经元的放电率通常较低，但这些神经元与脊柱前凸相关的活动与控制脊柱前凸的个体发作以及表现出脊柱前凸反应的状态相关倾向的作用是一致的。
