[脂质体膜表层结构对吩噻嗪类药物结合的影响]
[Effect of the structure of liposomal membrane surface layer on the binding of phenothiazines].
作者信息
Iarova E A, Deev A I, Kovaleva N S, Ivkov N N
出版信息
Farmakol Toksikol. 1978 Jan-Feb;41(1):8-12.
PMID:23960
Abstract
By using a fluorescent 3-metoxybenzatrone probe the binding of the phenothiazine series drugs (chlorpromazine, triftazine, aethaperazine) with phospholipid vesicles--liposomes, was investigated. Cholesterol is shown not to affect the binding of these drugs with liposomes. The surface charge of liposomes influences only the combination with the chlorpromazine membranes. With a higher positive charge of the membranes the binding of chlorpromazine diminishes in force.
摘要
通过使用荧光3 - 甲氧基苯并蒽酮探针，研究了吩噻嗪类药物（氯丙嗪、三氟拉嗪、乙哌立松）与磷脂囊泡——脂质体的结合情况。结果表明胆固醇不影响这些药物与脂质体的结合。脂质体的表面电荷仅影响与氯丙嗪膜的结合。随着膜的正电荷增加，氯丙嗪的结合力减弱。
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