Kar Sumit, Singh Neha
Department of Dermatology, Venereology and Leprosy, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.
Int J Trichology. 2013 Jan;5(1):47-9. doi: 10.4103/0974-7753.114708.
Phenol is an aromatic hydrocarbon derived from coal tar or manufactured from monochlorobenzene. Alopecia areata is a common non scarring autoimmune condition characterised by patchy loss of hair without atrophy. Various treatment modalities have been proposed and used for the treatment of alopecia areata, which is indeed a difficult condition to treat. Variable results have been documented using intralesional corticosteroid injections, topical minoxidil, topical anthralin ointment, topical contact sensitizers like diphencyprone, dinitrochlorobenzene or squaric acid dibutyl ester, and oral mini pulse with betamethasone. The use of 88% phenol for the treatment of alopecia areata has been documented in literature, but it has failed to secure a place in the priority list. Herein we have reported a case of a young girl who was treated with short-time aggressive therapy using 88% phenol and dexamethasone pulse therapy and who responded well to the treatment with no recurrence in the last 6 months of follow-up.
苯酚是一种从煤焦油中提取或由一氯苯制造的芳香烃。斑秃是一种常见的非瘢痕性自身免疫性疾病，其特征是局部脱发且无萎缩。已经提出并使用了各种治疗方法来治疗斑秃，斑秃确实是一种难以治疗的疾病。使用皮损内注射皮质类固醇、外用米诺地尔、外用蒽林软膏、外用接触致敏剂如二苯环丙烯酮、二硝基氯苯或二丁基二甲基丙烯酸酯以及口服倍他米松小剂量脉冲治疗，已记录到不同的结果。文献中已记载了使用88%苯酚治疗斑秃的情况，但它未能在优先治疗列表中占据一席之地。在此，我们报告了一例年轻女孩的病例，她接受了使用88%苯酚的短期积极治疗和地塞米松脉冲治疗，并且在随访的最后6个月中对治疗反应良好，未复发。
