Perriard-Wolfensberger J, Pasche-Koo F, Mainetti C, Labarthe M P, Salomon D, Saurat J H
Department of Dermatology, University Hospital Geneva, Switzerland.
Dermatology. 1993;187(4):282-5. doi: 10.1159/000247268.
In an attempt to stop the evolution of recent-onset severe alopecia areata (AA), we tested pulse corticotherapy on 9 patients. Acceptance into the study was based on the following criteria: recent-onset AA (< 1 year), AA in an active state, bald surface > 30% of the scalp, no contraindication to pulse corticotherapy. Each patient was given 250 mg i.v. of methylprednisolone twice a day on 3 successive days. In 8 patients the course of the ongoing episode of AA was stopped. At the 6-month follow-up, a regrowth on 80-100% of the bald surface was observed in 6 patients. One patient did not respond to treatment, and 2 had less than 50% of regrowth. This open study suggests that pulse corticotherapy: (1) can stop the course of severe AA in an active state, (2) is well tolerated without major side effects and (3) does not permit a stable control of AA of more than 1 year duration. This treatment seems to be indicated for severe AA of recent onset.
为了阻止近期发生的重度斑秃（AA）的病情发展，我们对9例患者进行了冲击性皮质类固醇疗法试验。纳入该研究的标准如下：近期发生的斑秃（<1年）、处于活动期的斑秃、秃发面积>头皮面积的30%、无冲击性皮质类固醇疗法的禁忌证。每位患者连续3天每天静脉注射250mg甲泼尼龙，每日2次。8例患者斑秃的病情发展得到控制。在6个月的随访中，6例患者秃发面积的80%-100%出现毛发再生。1例患者对治疗无反应，2例患者毛发再生少于50%。这项开放性研究表明，冲击性皮质类固醇疗法：（1）可以控制处于活动期的重度斑秃的病情发展，（2）耐受性良好，无严重副作用，（3）无法对病程超过1年的斑秃实现稳定控制。这种治疗方法似乎适用于近期发生的重度斑秃。
