一项关于癌旁正常涎腺组织中HER-2/neu表达及银结合核仁组织区（Ag NORs）的研究。
A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue.
作者信息
Gaballah Essam Taher M A
机构信息
Professor of Oral Pathology, Mansoura Faculty of Dentistry, Egypt.
出版信息
Saudi Dent J. 2010 Apr;22(2):89-94. doi: 10.1016/j.sdentj.2010.02.005. Epub 2010 Feb 10.
UNLABELLED
Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis.
OBJECTIVES
The present study was carried out to assess the immunohistochemical expression of HER-2/neu protein and of silver binding nucleolar organizer regions in normal salivary tissue.
MATERIALS AND METHODS
Twenty paraffin blocks of salivary tumors containing surrounding normal salivary tissue were used in the study. One section was processed to investigate HER-2/neu protein expression and another section was stained to assess the mean Ag NOR counts in normal salivary tissue.
RESULTS
Only two cases of the studied normal salivary tissue showed HER-2/neu expression (10%), which was expressed only in ductal cells with 4.2 ± 2.1 mean number of reactive cells per five high power fields (HPFs). Statistically significant (P = 0.01) higher mean Ag NOR counts in ductal (2 ± 0.83) than in acinar cells (1.2 ± 0.01) of normal salivary tissue were found.
CONCLUSION
It was concluded from the data of the present study that ductal cells of normal salivary tissue are a proliferative pool and an oncogenic target which plays an important role in the histogenesis of salivary gland tumors.
未标记
涎腺肿瘤包括组织发生不明的表型和生物学上多样的病变。
目的
本研究旨在评估HER-2/neu蛋白在正常涎腺组织中的免疫组化表达以及银结合核仁组织区的表达。
材料与方法
本研究使用了20个包含周围正常涎腺组织的涎腺肿瘤石蜡块。将其中一部分切片用于研究HER-2/neu蛋白表达，另一部分切片用于评估正常涎腺组织中的平均银染核仁组织者区（Ag NOR）计数。
结果
在所研究的正常涎腺组织中，仅2例（10%）显示HER-2/neu表达，仅在导管细胞中表达，每5个高倍视野（HPF）中反应性细胞的平均数量为4.2±2.1。发现正常涎腺组织导管细胞中的平均Ag NOR计数（2±0.83）在统计学上显著高于腺泡细胞（1.2±0.01）（P = 0.01）。
结论
从本研究的数据得出结论，正常涎腺组织的导管细胞是一个增殖池和致癌靶点，在涎腺肿瘤的组织发生中起重要作用。
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