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2
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Granulocyte colony-stimulating factor (G-CSF) production and G-CSF receptor structure in patients with congenital neutropenia.先天性中性粒细胞减少症患者的粒细胞集落刺激因子（G-CSF）产生及G-CSF受体结构
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本文引用的文献

1
Congenital Agranulocytosis (Kostmann's Syndrome) and G-CSF Therapy in an Infant.婴儿先天性粒细胞缺乏症（科斯特曼综合征）与粒细胞集落刺激因子治疗
Turk J Haematol. 1999 Dec 5;16(4):171-5.
2
The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report.严重慢性中性粒细胞减少症国际登记处：10年随访报告。
Support Cancer Ther. 2006 Jul 1;3(4):220-31. doi: 10.3816/SCT.2006.n.020.
3
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease).HAX1基因缺陷导致常染色体隐性遗传的严重先天性中性粒细胞减少症（科斯特曼病）。
Nat Genet. 2007 Jan;39(1):86-92. doi: 10.1038/ng1940. Epub 2006 Dec 24.
4
The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy.接受长期粒细胞集落刺激因子（G-CSF）治疗的严重先天性中性粒细胞减少症患者的白血病发病率和败血症死亡率。
Blood. 2006 Jun 15;107(12):4628-35. doi: 10.1182/blood-2005-11-4370. Epub 2006 Feb 23.
5
Update on childhood neutropenia: molecular and clinical advances.儿童中性粒细胞减少症的最新进展：分子与临床进展
Hematol Oncol Clin North Am. 2004 Dec;18(6):1439-58, x. doi: 10.1016/j.hoc.2004.06.013.
6
Retinal and extraocular cytomegalovirus end-organ disease in HIV-infected patients in Europe: a EuroSIDA study, 1994-2001.欧洲HIV感染患者的视网膜和眼外巨细胞病毒终末器官疾病：一项欧洲SIDA研究，1994 - 2001年
Eur J Clin Microbiol Infect Dis. 2004 Jul;23(7):550-9. doi: 10.1007/s10096-004-1160-2. Epub 2004 Jun 30.
7
Guidelines on the use of colony-stimulating factors in haematological malignancies.血液系统恶性肿瘤中集落刺激因子的使用指南
Br J Haematol. 2003 Oct;123(1):22-33. doi: 10.1046/j.1365-2141.2003.04546.x.
8
Infantile genetic agranulocytosis; agranulocytosis infantilis hereditaria.婴儿遗传性粒细胞缺乏症；遗传性婴儿粒细胞缺乏症
Acta Paediatr Suppl (Upps). 1956 Feb;45(Suppl 105):1-78.
9
Long-term follow-up of granulocyte colony-stimulating factor receptor mutations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy.严重先天性中性粒细胞减少症患者粒细胞集落刺激因子受体突变的长期随访：对白血病发生和治疗的意义。
Br J Haematol. 2003 Feb;120(4):685-90. doi: 10.1046/j.1365-2141.2003.04160.x.
10
Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry.严重慢性中性粒细胞减少症：国际严重慢性中性粒细胞减少症登记处患者的治疗与随访
Am J Hematol. 2003 Feb;72(2):82-93. doi: 10.1002/ajh.10255.

高剂量造血细胞集落刺激因子相关性白内障：病例报告及文献复习。

Cataract associated with high-dose hematopoietic colony stimulating factor, case report and literature review.

机构信息

Haematology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

出版信息

Saudi Pharm J. 2010 Apr;18(2):107-10. doi: 10.1016/j.jsps.2010.02.008. Epub 2010 Feb 14.

DOI:10.1016/j.jsps.2010.02.008
PMID:23960727
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3730976/
Abstract

Granulocyte-colony stimulating factor (G-CSF) is a lineage-restricted hematopoietic growth factor. It induces proliferation and maturation of neutrophilic precursors and progenitors and activates neutrophil functions. It is used to ameliorate or prevent profound neutropenia and its consequences. G-CSF therapy in neutropenic disorders increases neutrophil count and improves infectious complications. However, it is not without side effects. Here, we discuss the case of a 2 years old patient with Kostmann's disease who developed cataracts following high-dose G-CSF therapy. We also review the relevant literature on G-CSF-related complications.

摘要

粒细胞集落刺激因子（G-CSF）是一种谱系限制的造血生长因子。它诱导中性粒细胞前体和祖细胞的增殖和成熟，并激活中性粒细胞功能。它用于改善或预防严重的中性粒细胞减少症及其后果。G-CSF 治疗中性粒细胞减少症可增加中性粒细胞计数并改善感染并发症。然而，它并非没有副作用。在这里，我们讨论了一例 Kostmann 病患者的病例，该患者在接受高剂量 G-CSF 治疗后出现白内障。我们还回顾了与 G-CSF 相关并发症相关的文献。