图释 rheumavedic 胶囊的抗风湿机制。
Illustration of anti-rheumatic mechanism of rheumavedic capsule.
机构信息
Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, 22nd main, 24th cross, Banashankari IInd Stage, Bangalore, Karnataka 560 070, India.
出版信息
Saudi Pharm J. 2011 Oct;19(4):279-84. doi: 10.1016/j.jsps.2011.07.002. Epub 2011 Jul 22.
The present study was taken up to illustrate the mechanism of anti-rheumatic activity of 'Rheumavedic capsule', a polyherbal formulation of Vedic-bio Labs, Bangalore, in adjuvant induced arthritic rats. Anti-inflammatory mechanism is illustrated using phlogistic agents induced paw edema in rats. Analgesic mechanism is illustrated using Eddy's hot plate and acetic acid (0.6%v/v) induced writhing in mice. Histopathology of knee joint was studied. Rheumavedic showed inhibition of inflammation mediated through Histamine, 5-Hydroxy tryptamine, and Bradykinin. Rheumavedic showed protection in both acetic acid and Eddy's hot plate induced pain. Histopathology of knee joint of rat pre-treated with rheumavedic showed significant reduction in the mononuclear infiltration, pannus formation and adhesion molecules. The anti-rheumatic mechanism of rheumavedic is due to; inhibition of inflammatory mediators i.e., Histamine, 5-Hydroxy tryptamine and Bradykinin., protection against prostaglandins mediated pain, by inhibiting cyclo-oxygenase synthesis and reduction in pannus formation, by inhibiting mononuclear infiltration.
本研究旨在阐明印度草药生物实验室的多草药制剂“Rheumavedic 胶囊”在佐剂诱导关节炎大鼠中的抗风湿作用机制。使用炎症介质诱导大鼠爪肿胀来阐明抗炎机制。使用 Eddy 热板和乙酸（0.6%v/v）诱导小鼠扭体来阐明镇痛机制。研究了膝关节的组织病理学。Rheumavedic 显示通过组胺、5-羟色胺和缓激肽介导的炎症抑制。Rheumavedic 在乙酸和 Eddy 热板诱导的疼痛中均有保护作用。用 rheumavedic 预处理的大鼠膝关节的组织病理学显示单核细胞浸润、血管翳形成和粘附分子显著减少。Rheumavedic 的抗风湿机制是由于：抑制炎症介质，即组胺、5-羟色胺和缓激肽。通过抑制环氧化酶合成和减少血管翳形成来防止前列腺素介导的疼痛，通过抑制单核细胞浸润。
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