Fennich Nada, Ellouali Fedoua, Abdelali Salima, Chaara Assad, Berrada Allal, Elhajjaji Imane, Cherradi Rhizlane, Abir Saadia, Doghmi Nawal, Cherti Mohammed
Cardiology B Department, Ibn Sina University Hospital, Secteur 16 bloc I num 8, Hay Riad, Rabat, Morocco.
Cardiovasc Ultrasound. 2013 Aug 20;11:30. doi: 10.1186/1476-7120-11-30.
Stress echocardiography is a valuable tool for the noninvasive diagnosis of ischemic heart disease. Despite its widely use in the clinical practice, safety and side effects profile have never been evaluated in Moroccans.
To assess the safety and tolerability of the two stress echo modalities in Moroccans.
The study was made by 311 patients with known or suspected coronary artery disease, 203 underwent exercise echocardiography and 108 underwent dobutamine echocardiography, major and minor rhythmic complications and side effects were recorded for the two groups.
We registered 3 (2, 8%) major rhythmic events in the dobutamine group (2 sustained supraventricular tachycardia and 1 sustained ventricular tachycardia), there was no major rhythmic events in the exercise group. Minor rhythmic events were frequent (43, 5% in the dobutamine group and 19, 2% in the exercise group with a p = 0, 0001). Severe hypotension occurs in 4 (3, 7%) patients during a dobutamine stress, there was no significant drop in the blood pressure during exercise stress procedures. Non cardiac side effects were more common among patients who underwent a dobutamine stress echo (13, 9% vs. 3, 4% with p = 0,001).
Exercise is safer than dobutamine stress echocardiography, complications and adverse effects with the use of dobutamine are usually minor and self-limiting.
负荷超声心动图是缺血性心脏病无创诊断的重要工具。尽管其在临床实践中广泛应用,但摩洛哥人群中其安全性和副作用情况从未得到评估。
评估两种负荷超声心动图检查方式在摩洛哥人群中的安全性和耐受性。
该研究纳入311例已知或疑似冠心病患者,其中203例行运动负荷超声心动图检查,108例行多巴酚丁胺负荷超声心动图检查,记录两组患者的主要和次要节律并发症及副作用。
多巴酚丁胺组记录到3例(2.8%)主要节律事件(2例持续性室上性心动过速和1例持续性室性心动过速),运动组未发生主要节律事件。次要节律事件较为常见(多巴酚丁胺组为43.5%,运动组为19.2%,p = 0.0001)。多巴酚丁胺负荷试验中有4例(3.7%)患者出现严重低血压,运动负荷试验过程中血压无显著下降。非心脏副作用在接受多巴酚丁胺负荷超声心动图检查的患者中更为常见(13.9%对3.4%,p = 0.001)。
运动负荷超声心动图比多巴酚丁胺负荷超声心动图更安全,使用多巴酚丁胺的并发症和不良反应通常较轻且为自限性。