Gališinová Jana, Andriamainty Fils, Malík Ivan, Cizmarik Jozef, Sichrovská L'ubica
Department of Pharmaceutical Chemistry, Comenius University, Bratislava, Slovak Republic.
Ceska Slov Farm. 2013 Jun;62(3):132-5.
The formation of micelles of the local anaesthetic pentacaine hydrochloride (K 1902) in methanol solutions at two concentrations was investigated by measuring the absorbance of pyrene in surfactant solution. The absorbance vs. surfactant concentration profiles for all the major UV spectral peaks of pyrene have been found to be sigmoidal in nature which were analyzed according to Sigmoidal-Boltzmann equation to evaluate the cmcs values of the studied systems. The influence of the methanol concentration on the critical micellar concentration was studied. The observed critical micellar concentration rises with an increasing of alcohol.
通过测量芘在表面活性剂溶液中的吸光度，研究了两种浓度的盐酸戊卡因（K 1902）在甲醇溶液中胶束的形成。芘所有主要紫外光谱峰的吸光度与表面活性剂浓度曲线呈S形，根据S形玻尔兹曼方程对其进行分析，以评估所研究体系的临界胶束浓度（cmc）值。研究了甲醇浓度对临界胶束浓度的影响。观察到临界胶束浓度随醇含量的增加而升高。
