Department of Dermatology and Allergology, Ludwig-Maximilian University, Munich, Germany.
J Dermatol. 2013 Oct;40(10):779-85. doi: 10.1111/1346-8138.12255. Epub 2013 Aug 21.
The main interests covered in this article are the determination of risk factors and incidence of surgical site infections in dermatosurgery and suggestions for rational use of antibiotic prophylaxis. A total of 3284 consecutive dermatosurgical interventions in 1088 patients were performed in our dermatosurgery department. Data regarding patient characteristics and perioperative course were prospectively collected and retrospective analysis of this data was performed. Association of perioperative parameters and postoperative surgical site infections was assessed by χ(2) -test. Rate of postoperative infections in our study was low (1.9%). Purulent surgical sites showed the highest incidence of severe postoperative infections (4.7%; P < 0.001). The lowest incidence of mild infections was seen in preoperatively clean surgical sites (0.8%; P < 0.001). All patients with severe infections and 68% patients with mild infections were older than 70 years. The head and neck and acral regions were the groups mostly affected by mild postoperative conditions (2.4% and 1.7%, respectively; P = 0.006). The frequency of mild and severe infections in procedures performed by experienced surgeons was lower than in procedures performed by less experienced surgeons (0.6% vs 3.1% in mild infections, 0.1 vs 0.8 in severe infections; P < 0.001). The main risk factors for postoperative infections were wounds in the head and neck region, lips and oral mucosa or acral regions, older age of patients, worse preoperative state of surgical sites and less experienced surgeons. In the majority of cases where risk factors were missing there was no need of antibiotic prophylaxis.
本文主要关注的是皮肤科手术中手术部位感染的危险因素和发生率的确定,以及抗生素预防用药的合理使用的建议。我们皮肤科对 1088 例患者的 3284 例连续皮肤科手术进行了回顾性分析。前瞻性收集了患者特征和围手术期数据,并对这些数据进行了回顾性分析。采用卡方检验评估围手术期参数与术后手术部位感染的相关性。本研究中术后感染率较低(1.9%)。化脓性手术部位的严重术后感染发生率最高(4.7%;P<0.001)。术前清洁手术部位的轻度感染发生率最低(0.8%;P<0.001)。所有严重感染患者和 68%的轻度感染患者年龄均大于 70 岁。头颈部和肢端区域是受轻度术后情况影响最大的群体(分别为 2.4%和 1.7%;P=0.006)。经验丰富的外科医生手术中轻度和重度感染的发生率低于经验较少的外科医生(轻度感染时为 0.6%比 3.1%,重度感染时为 0.1%比 0.8%;P<0.001)。术后感染的主要危险因素包括头颈部、嘴唇和口腔黏膜或肢端区域的伤口、患者年龄较大、手术部位术前状况较差以及外科医生经验不足。在大多数情况下,如果没有危险因素,就不需要抗生素预防用药。