a Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and University of Texas-Houston Medical School , Houston , Texas , USA.
Child Neuropsychol. 2014;20(5):495-508. doi: 10.1080/09297049.2013.822059. Epub 2013 Aug 20.
Low birth weight (LBW; below 2500 grams) is a general risk factor for a variety of neurodevelopmental difficulties. However, these children may remain more vulnerable to neurologic and environmental insults occurring years later. This prospective case series reports on children who sustained a mild, moderate, or severe traumatic brain injury (TBI) in middle childhood but who had also been born with birth weights below 2500 grams.
PARTICIPANTS were 14 children with mild, moderate, or severe traumatic brain injury (TBI), 5 of whom had birth weights under 2500 grams (LBW) and 9 children with normal birth weight (NBW). All participants were drawn from a larger study on the long-term cognitive and behavioral impact of pediatric TBI and were matched on age, estimated socioeconomic status (SES), and severity of TBI (with NBW children actually having a slightly worse overall injury severity).
At baseline, both groups exhibited similar scores on WJ-R Letter Word Identification and Calculations, Tower of London number solved, and CVLT-C total correct. Baseline group differences were observed on the CELF-III Formulated Sentences (NBW > LBW) and on the VABS Adaptive Behavior Composite and Socialization subdomain (LBW > NBW). Over 2 years, relative to the NBW group, the LBW group evidenced declines on both WJ-R subtests, CVLT-C total correct, CELF-III Formulated Sentences, and VABS Adaptive Behavior Composite and Socialization.
Although preliminary in nature due to small sample size, findings suggest a history of LBW influences the recovery trajectory following childhood TBI. Academic and adaptive functioning and verbal memory appeared particularly affected.
低出生体重（LBW；低于 2500 克）是多种神经发育困难的一般危险因素。然而，这些儿童在多年后可能仍然更容易受到神经和环境的伤害。本前瞻性病例系列报告了在儿童中期遭受轻度、中度或重度创伤性脑损伤（TBI）但出生体重低于 2500 克的儿童。
参与者为 14 名患有轻度、中度或重度创伤性脑损伤（TBI）的儿童，其中 5 名出生体重低于 2500 克（LBW），9 名儿童出生体重正常（NBW）。所有参与者均来自一项关于儿科 TBI 的长期认知和行为影响的更大研究，并按年龄、估计社会经济地位（SES）和 TBI 严重程度进行匹配（NBW 儿童实际上整体损伤严重程度略差）。
在基线时，两组在 WJ-R 字母词识别和计算、伦敦塔数字解决以及 CVLT-C 总正确方面的得分相似。在 CELF-III 结构式句子（NBW > LBW）和 VABS 适应行为综合和社交领域（LBW > NBW）上观察到基线组差异。在 2 年期间，与 NBW 组相比，LBW 组在 WJ-R 两个子测试、CVLT-C 总正确、CELF-III 结构式句子和 VABS 适应行为综合和社交方面的得分均下降。
尽管由于样本量小，结果初步表明 LBW 病史会影响儿童 TBI 后的恢复轨迹。学业和适应功能以及言语记忆似乎受到特别影响。
