一种来自菊科植物糙叶败酱（Rudbeckia hirta L.）花的新型高含氧伪愈创木烷内酯和 5-脂氧合酶抑制活性。
A new highly oxygenated pseudoguaianolide with 5-LOX inhibitory activity from Rudbeckia hirta L. flowers.
机构信息
a Department of Pharmacognosy, Faculty of Pharmacy , Mansoura University (MU) , Mansoura , 35516 , Egypt.
出版信息
Nat Prod Res. 2013;27(24):2281-5. doi: 10.1080/14786419.2013.825916. Epub 2013 Aug 20.
A new highly oxygenated pseudoguaianolide, rudbeckolide (1), was isolated from Rudbeckia hirta L. flowers. The structure of this terpenoid lactone was established on the basis of extensive 1D and 2D NMR spectroscopic analyses. The compound exhibited strong 5-lipoxygenase inhibitory activity (84.9% inhibition at 10 μg/mL) in vitro and the result provided partial evidence for the usage of the plant as traditional medicine.
从菊科植物糙叶斑鸠菊（Rudbeckia hirta L.）的花朵中分离得到一种新型高氧化伪愈创木烷内酯，鲁德贝醇内酯（1）。该萜类内酯的结构是基于广泛的 1D 和 2D NMR 光谱分析确定的。该化合物在体外表现出很强的 5-脂氧合酶抑制活性（在 10 μg/mL 时抑制率为 84.9%），这一结果为该植物作为传统药物的应用提供了部分依据。
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