School of Biotechnology, Gautam Buddha University, Greater Noida, India.
Med Mycol. 2014 Jan;52(1):2-9. doi: 10.3109/13693786.2013.819592.
Aspergillus fumigatus is a well adapted, opportunistic fungus that causes a severe and commonly fatal disease, invasive pulmonary aspergillosis (IPA), in highly immunocompromised patients, aspergilloma in patients with lung cavities and allergic bronchopulmonary aspergillosis (ABPA) in hypersensitive individuals. Recent studies have suggested that biofilm formation by A. fumigatus may be one of the most important virulence factors in IPA and aspergilloma. Several fungal constituents may contribute to the formation of biofilm structures on host cells, including cell wall components, secondary metabolites and drug transporters. The biofilm phenotype of the fungus is refractory to most conventional antifungal treatment options. Thus, an in-depth analysis and understanding of A. fumigatus biofilms is necessary to devise newer and better antifungal targets for treating complex A. fumigatus biofilm-associated diseases.
烟曲霉是一种适应性强的机会致病菌，可导致严重且通常致命的疾病，包括免疫功能低下患者的侵袭性肺曲霉病（IPA）、肺空洞患者的曲霉肿和过敏个体的变应性支气管肺曲霉病（ABPA）。最近的研究表明，烟曲霉的生物膜形成可能是 IPA 和曲霉肿最重要的毒力因素之一。一些真菌成分可能有助于在宿主细胞上形成生物膜结构，包括细胞壁成分、次级代谢产物和药物转运蛋白。真菌的生物膜表型对大多数常规抗真菌治疗方法具有耐药性。因此，深入分析和了解烟曲霉生物膜对于设计新型更好的抗真菌靶点以治疗复杂的烟曲霉生物膜相关疾病是必要的。
