Salatino Adriana, Berra Eliana, Troni Walter, Sacco Katiuscia, Cauda Franco, D'Agata Federico, Geminiani Giuliano, Duca Sergio, Dimanico Ugo, Ricci Raffaella
a Department of Psychology , University of Turin , Turin , Italy.
Neurocase. 2014;20(6):615-26. doi: 10.1080/13554794.2013.826691. Epub 2013 Aug 21.
Repetitive Transcranial Magnetic Stimulation (rTMS) ameliorates motor and neuropsychological deficits following stroke, but little is known about the underlying neuroplasticity. We investigated neuroplastic changes following 5 days of low-frequency rTMS on the intact motor cortex to promote motor recovery in a chronic patient with subcortical stroke. The feasibility of administering multiple treatments was also assessed 6 months later by applying the same protocol over the patient's parietal cortex to improve visuospatial disorders. Behavioral improvements and no adverse events were observed. Neuroimaging findings indicated that motor symptoms amelioration was associated with downregulation and cortical reorganization of hyperactive contralesional hemisphere.
重复经颅磁刺激（rTMS）可改善中风后的运动和神经心理缺陷，但对其潜在的神经可塑性知之甚少。我们研究了在一名慢性皮质下中风患者的完整运动皮层上进行5天低频rTMS后的神经可塑性变化，以促进运动恢复。6个月后，通过在患者顶叶皮层应用相同方案来改善视觉空间障碍，还评估了多次治疗的可行性。观察到行为改善且无不良事件。神经影像学结果表明，运动症状的改善与对侧过度活跃半球的下调和皮质重组有关。
