犬体内血管活性肠肽对乙醇的反应。

Vasoactive intestinal polypeptide response to ethanol in dogs.

作者信息

Misawa T, Aramaki J, Chijiiwa Y, Kabemura T, Nasu T, Nawata H

机构信息

Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.

出版信息

Tohoku J Exp Med. 1990 May;161(1):49-54. doi: 10.1620/tjem.161.49.

DOI:10.1620/tjem.161.49

PMID:2396256

Abstract

Only one report has described the ethanol-induced release of vasoactive intestinal polypeptide (VIP), and its mechanism of action is unknown. We studied changes in mesenteric immunoreactive VIP (IR-VIP) concentrations following the intrajejunal administration of 100 ml of normal saline, 5% and 10% ethanol, and hypertonic saline which was isoosmolar to 10% ethanol (1,670 mOsm/liter) in dogs. Administration of 5% and 10% ethanol resulted in significant and dose-dependent increases in mesenteric IR-VIP. Mesenteric IR-VIP changes and incremental integrated responses to 10% ethanol and to hypertonic saline were the same. We concluded that ethanol-induced VIP release in dogs is mainly due to ethanol's hyperosmolarity.

摘要

仅有一篇报告描述了乙醇诱导的血管活性肠肽（VIP）释放，但其作用机制尚不清楚。我们研究了在犬空肠内给予100毫升生理盐水、5%和10%乙醇以及与10%乙醇等渗（1670毫渗摩尔/升）的高渗盐水后肠系膜免疫反应性VIP（IR-VIP）浓度的变化。给予5%和10%乙醇导致肠系膜IR-VIP显著且呈剂量依赖性增加。肠系膜IR-VIP的变化以及对10%乙醇和高渗盐水的增量综合反应是相同的。我们得出结论，犬体内乙醇诱导的VIP释放主要是由于乙醇的高渗性。