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[抗糖尿病药物的法医化学测定]

[The forensic chemical determination of antidiabetic agents].

作者信息

Muzhanovskiĭ E B, Fartushnyĭ A F, Sukhin A P, Sedov A I

出版信息

Sud Med Ekspert. 1990 Apr-Jun;33(2):38-40.

PMID:2396290
Abstract

Method of detection, purification and determination of some antidiabetic agents (ADA)--bucarban, butamid, glybenclamid, glybutide, methformine, prediane, chlorpropamide, chlocyclamide, cyclamide in biological material was developed. Microcrystalline reaction with 10% alcoholic potassium iodide, colour reactions and investigation by TLC method both native substances and nitration products were developed to identify ADA. The assay is performed by spectrophotometry. Detection limit is 2-5 mg of each substance in 50 g of the material.

摘要

已开发出检测、纯化和测定生物材料中某些抗糖尿病药物(ADA)——布卡班、丁磺酰胺、格列本脲、格列丁脲、二甲双胍、泼尼松龙、氯磺丙脲、氯环酰胺、环磷酰胺的方法。利用与10%乙醇碘化钾的微晶反应、颜色反应以及通过TLC法对天然物质和硝化产物进行研究来鉴定ADA。该测定通过分光光度法进行。检测限为50 g材料中每种物质2 - 5 mg。

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