Antonenko L V, Kholodova Iu D, Apukhovskaia L I, Voziian P A, Solodova E V, Kvashnina L V
Ukr Biokhim Zh (1978). 1990 May-Jun;62(3):54-9.
The lipid composition and structure of low- and high-density lipoproteins (LDL and HDL) have been studied in children with the vitamin D-deficient rachitis. An increase of the cholesterol content in the atherogenic LDL against a background of its decrease in the antiatherogenic HDL has been revealed, that is analogous to the observed changes under the atherosclerosis development in adults. Due to the studies in the amino acidic composition and determination of the nature and quantity of the charged groups of lipoprotein particles accessible for titration definite, certain disturbance in the structure of lipoproteins are observed as such that may cause disturbances in their functional activity.
对维生素D缺乏性佝偻病患儿的低密度脂蛋白和高密度脂蛋白（LDL和HDL）的脂质组成及结构进行了研究。结果显示，致动脉粥样硬化的LDL中胆固醇含量增加，而抗动脉粥样硬化的HDL中胆固醇含量减少，这与成人动脉粥样硬化发展过程中观察到的变化类似。通过对脂蛋白颗粒可滴定的带电基团的性质和数量进行测定以及对氨基酸组成的研究，发现脂蛋白结构存在一定紊乱，这种紊乱可能导致其功能活性受到干扰。
