Department of Orthodontics, Medical Centre of the Johannes-Gutenberg-University Mainz, Augustusplatz 2, Mainz 55131, Germany.
Head Face Med. 2013 Aug 21;9:22. doi: 10.1186/1746-160X-9-22.
Recently, research has focused intensely on age-related tissue changes, not only in the field of dermatology but also in dental sciences. Although many new insights into age-related morphological, ultrastructural and biochemical changes in the periodontal ligament tissue have been gained, the basic question of whether there is a quantitative change in cell number remains unanswered or, at least to date, unpublished. Thus, the aim of this study was to detect age-related changes of the periodontal ligament regarding fibroblast density.
33 lateral tooth-bearing segments of the maxilla were obtained from deceased human individuals of different age, ranging from 7 to 63 years. The buccal segment of the periodontal ligament of the mesiobuccal root of the first maxillary molar was evaluated histomorphometrically to obtain the fibroblast density.
The results clearly indicate a steady and statistically significant decline of fibroblast number with age.
It may be concluded that fibroblast density in the physiological human periodontal ligament tissue decreases with age, thus causing an initial delay in physiological, pathological or externally induced processes that require remodeling of the periodontal ligament, e.g. traumatic occlusion or orthodontic tooth movement. It may be assumed that an orthodontic tooth movement in elderly patients requires more time in the initial treatment phase and should be done with lighter forces.
最近，研究人员不仅在皮肤科领域，而且在牙科领域都集中研究了与年龄相关的组织变化。尽管人们对牙周膜组织中与年龄相关的形态、超微结构和生化变化有了许多新的认识，但关于细胞数量是否发生定量变化的基本问题仍未得到解答，或者至少到目前为止还没有发表。因此，本研究旨在检测牙周膜与成纤维细胞密度相关的年龄相关性变化。
从 7 至 63 岁不同年龄段的已故个体中获得 33 个上颌侧牙段。对第一磨牙近中颊根的颊侧牙周膜进行组织形态计量学评估，以获得成纤维细胞密度。
结果清楚地表明，成纤维细胞数量随年龄呈稳定且具有统计学意义的下降。
可以得出结论，生理状态下人牙周膜组织中成纤维细胞密度随年龄增长而降低，从而导致生理、病理或外部诱导过程的初始延迟，这些过程需要牙周膜的重塑，例如创伤性咬合或正畸牙齿移动。可以假设，老年患者的正畸牙齿移动在初始治疗阶段需要更多的时间，并且应该使用较轻的力。
