Rennels M L, Blaumanis O R, Grady P A
Department of Neurology, University of Maryland, School of Medicine, Baltimore 21201.
Adv Neurol. 1990;52:431-9.
Solutes in CSF have rapid access to ECS throughout the CNS (within 5-10 min). This occurs by solute/fluid influx through PVS around penetrating arteries, followed by longitudinal spread along the BL of capillaries to reach venules and veins. These paravascular pathways can be demonstrated light-microscopically by infusion of the tracer protein, HRP, into SAS and the subsequent localization of this probe molecule in brain sections using the sensitive histochemical method based on TMB. This unidirectional tracer/fluid movement along the intraparenchymal vascular network, with accompanying spread into the cerebral interstitium, appears to be facilitated by the pulsation of penetrating arterioles within their PVS with each cardiac contraction.
脑脊液中的溶质可在整个中枢神经系统内迅速进入细胞外间隙（5 - 10分钟内）。这是通过溶质/液体经穿通动脉周围的血管周围间隙流入，随后沿毛细血管基底膜纵向扩散至小静脉和静脉来实现的。通过将示踪蛋白辣根过氧化物酶注入蛛网膜下腔，并使用基于3,3',5,5'-四甲基联苯胺的灵敏组织化学方法在脑切片中定位该探针分子，可在光学显微镜下显示这些血管周围通路。这种沿着实质内血管网络的单向示踪剂/液体移动，伴随着扩散到脑间质，似乎是由穿通小动脉在其血管周围间隙内随每次心脏收缩的搏动所促进的。
