可直接从疾病预防控制中心获得用于治疗自由生活阿米巴感染的研究性药物。
Investigational drug available directly from CDC for the treatment of infections with free-living amebae.
出版信息
MMWR Morb Mortal Wkly Rep. 2013 Aug 23;62(33):666.
Abstract
Infections caused by free-living amebae (FLA) are severe and life-threatening. These infections include primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri and granulomatous amebic encephalitis caused by Balamuthia mandrillaris and Acanthamoeba species. Although several drugs have in vitro activity against FLA, mortality from these infections remains>90% despite treatment with combinations of drugs.
摘要
由自由生活阿米巴（FLA）引起的感染严重且危及生命。这些感染包括由纳氏福氏虫引起的原发性阿米巴脑膜脑炎（PAM）和由曼氏巴利西亚虫和棘阿米巴属引起的肉芽肿性阿米巴脑炎。尽管有几种药物对 FLA 具有体外活性，但即使联合使用多种药物治疗，这些感染的死亡率仍>90%。
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本文引用的文献
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