Hoskins B, Vroom F Q, Jarrell M A
Arch Neurol. 1975 Aug;32(8):519-23. doi: 10.1001/archneur.1975.00490500039003.
Effects of strenous exercise, followed by rest, and of potassium administration on blood chemistry values were studied in two patients with hyperkalemic periodic paralysis and in normal volunteers. These procedures produced attacks of flaccid paralysis that occurred concomitantly with rapid rises in serum potassium concentrations and decreases in blood glucose and inorganic phosphate levels. With the exception of the serum potassium level which rose following exercise and potassium administration, there were no changes in the blood chemistry values of the normal volunteers. During the induced attacks of paralysis, the expired breath of the patients had a very strong odor of ketosis. Results of subsequent glucose tolerance tests were abnormal. Following 24 hour administration of acetazolamide, the studies were repeated. The drug appeared to cause lesser effects of stimuli on serum potassium levels and a stabilizing effect on blood glucose levels.
对两名高钾性周期性麻痹患者和正常志愿者进行了研究，观察剧烈运动后休息以及补钾对血液化学值的影响。这些操作引发了弛缓性麻痹发作，发作时血清钾浓度迅速升高，血糖和无机磷水平降低。除了运动和补钾后血清钾水平升高外，正常志愿者的血液化学值没有变化。在诱发的麻痹发作期间，患者呼出的气息有很强的酮症气味。随后的葡萄糖耐量试验结果异常。给予乙酰唑胺24小时后，重复进行这些研究。该药物似乎对刺激血清钾水平的作用较小，对血糖水平有稳定作用。
