什么是基因组？

What is a genome?

机构信息

Institute of Environmental Sciences, Jagiellonian University,Gronostajowa 7, 30-387 Kraków, Poland.

出版信息

Mol Ecol. 2013 Jul;22(13):3437-43. doi: 10.1111/mec.12355.

Abstract

The field of genomics is expanding rapidly, yet the meanings of the word ‘genome’ have yet to be conceptualized in explicit, coherent and useful frameworks. We develop and apply an evolutionary conceptualization of the genome,which represents a logical extension of the evolutionary definition of a gene developed by George C.Williams. An evolutionary genome thus represents a set of genetic material, in a lineage, that due to common interests tends to favour the same or similar phenotypes.This conceptualization provides novel perspectives on genome functions, boundaries and evolution, which should help to guide theoretical and empirical genomics research.

摘要

基因组学领域正在迅速发展，但“基因组”一词的含义尚未在明确、连贯和有用的框架中得到概念化。我们开发并应用了一种基因组的进化概念化，这是乔治·C·威廉姆斯（George C.Williams）提出的基因进化定义的逻辑延伸。因此，一个进化的基因组代表了一个谱系中的一组遗传物质，由于共同的利益，它往往倾向于支持相同或相似的表型。这种概念化提供了关于基因组功能、边界和进化的新视角，这应该有助于指导理论和经验基因组学研究。