Kodama Masaaki, Murakami Kazunari, Okimoto Tadayoshi, Fujioka Toshio
Department of Gastroenterology, Faculty of Medicine, Oita University.
Nihon Rinsho. 2013 Aug;71(8):1442-8.
Helicobacter pylori (H. pylori) is a major pathogen of chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Atrophic gastritis and intestinal metaplasia are recognized as precancerous lesion of gastric cancer. Many studies reported that H. pylori eradication had the preventive effect of gastric cancer. Moreover many studies mentioned the improvement of gastric atrophy and/or intestinal metaplasia. Two meta-analysis indicated the improvement of atrophic gastritis but not of intestinal metaplasia. In our study, intestinal metaplasia improved at lesser curvature of the corpus six years after eradication. H. pylori eradication has benefit for gastric cancer prevention provably due to improvement of the precancerous lesion such as atrophic gastritis and intestinal metaplasia. Especially, H. pylori eradication before the appearance of atrophy and intestinal metaplasia has been considered to be effective in inhibiting the development of gastric cancer. Therefore, improvement or elimination of chronic gastritis with H. pylori eradication might have possibility of gastric cancer inhibition.
幽门螺杆菌（H. pylori）是慢性萎缩性胃炎、肠化生和胃癌的主要病原体。萎缩性胃炎和肠化生被认为是胃癌的癌前病变。许多研究报告称，根除幽门螺杆菌对胃癌有预防作用。此外，许多研究提到了胃萎缩和/或肠化生的改善。两项荟萃分析表明萎缩性胃炎有所改善，但肠化生没有改善。在我们的研究中，根除幽门螺杆菌六年之后，胃体小弯处的肠化生有所改善。根除幽门螺杆菌对预防胃癌有益，这可能是由于改善了萎缩性胃炎和肠化生等癌前病变。特别是，在萎缩和肠化生出现之前根除幽门螺杆菌被认为对抑制胃癌的发展有效。因此，通过根除幽门螺杆菌改善或消除慢性胃炎可能具有抑制胃癌的可能性。
