Standaert D, Laurent F, Jonckheere S, Scheiff J M, Vandercam B, Yombi J C
Department of Internal Medicine - Infectious Diseases, HIV Reference Center, Cliniques Universitaires St Luc, Woluwé-Saint-Lambert, Brussels, Belgium.
Acta Clin Belg. 2013 Mar-Apr;68(2):124-7. doi: 10.2143/ACB.3207.
Leishmaniasis, an intracellular protozoal infection in which tissue macrophages are targeted, is transmitted by female sandfly bite and occurs in 98 countries. Visceral leishmaniasis (VL) is the clinical form of leishmaniasis most frequently associated with HIV, especially in Europe. Both diseases have a synergistic detrimental effect on the cellular immune response. Treatment of VL in patients with underlying HIV-infection is associated with lower cure rates, higher rates of drug toxicity, higher relapse rates and greater mortality than treatment of VL in immunocompetent patients. We report the case of a HIV-1 infected patient with advanced disease who presented VL with multiple relapses. This case highlights the difficulties of treating VL in patients with HIV co-infection.
利什曼病是一种细胞内原生动物感染，其靶细胞为组织巨噬细胞，通过雌性白蛉叮咬传播，在98个国家均有发生。内脏利什曼病（VL）是利什曼病最常与HIV相关的临床类型，尤其是在欧洲。这两种疾病对细胞免疫反应具有协同有害作用。与免疫功能正常的患者相比，对合并HIV感染的患者进行VL治疗的治愈率较低、药物毒性发生率较高、复发率较高且死亡率更高。我们报告了1例患有晚期疾病的HIV-1感染患者，该患者出现多次复发的VL。该病例凸显了合并HIV感染患者治疗VL的困难。
