Jacobs G, Cornelius L, Keene B, Rakich P, Shug A
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Am J Vet Res. 1990 Sep;51(9):1349-51.
Concentrations of total, free, and esterified carnitine were determined in plasma, liver, and skeletal muscle from cats with idiopathic hepatic lipidosis and compared with values from healthy cats. The mean concentrations of plasma, liver, and skeletal muscle total carnitine; plasma and skeletal muscle free carnitine; and plasma and liver esterified carnitine were greater (P less than 0.05) in cats with idiopathic hepatic lipidosis than in control cats. The mean for the ratio of free/total carnitine in plasma and liver was lower (P less than 0.05) in cats with idiopathic hepatic lipidosis than in control cats. These data suggest that carnitine deficiency does not contribute to the pathogenesis of feline idiopathic hepatic lipidosis.
测定了特发性肝脂肪变性猫的血浆、肝脏和骨骼肌中总肉碱、游离肉碱和酯化肉碱的浓度，并与健康猫的值进行比较。特发性肝脂肪变性猫的血浆、肝脏和骨骼肌总肉碱；血浆和骨骼肌游离肉碱；以及血浆和肝脏酯化肉碱的平均浓度高于（P < 0.05）对照猫。特发性肝脂肪变性猫血浆和肝脏中游离/总肉碱的平均比值低于（P < 0.05）对照猫。这些数据表明肉碱缺乏与猫特发性肝脂肪变性的发病机制无关。
