Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy; Department di Neuroscience, University of Parma, Parma, Italy.
Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy.
Clin Neurophysiol. 2014 Feb;125(2):239-49. doi: 10.1016/j.clinph.2013.07.009. Epub 2013 Aug 19.
To evaluate the spectral and spatial features of the cortical rhythms in patients affected by ring chromosome 20 - [r(20)]-syndrome.
Twelve patients with [r(20)] syndrome were studied. As controls we enrolled 12 patients with idiopathic generalized epilepsy (IGE) and 12 healthy volunteers (HV). Blind source separation, spectral analyses and source reconstruction were applied in all cases in order to identify reliable spatio-temporal patterns of cortical activity.
A theta-delta EEG rhythm was identified in [r(20)] patients, with spectral peak ranging between 3 and 7Hz and whose generators mapped over the sensory-motor cortices. A second peak laying at a frequency about double with respect to the first one was present in 6 cases. Analogue methodological approach in HV and IGE groups failed to show similar findings.
EEG of [r(20)] patients reveals the existence of a highly reproducible EEG pattern arising from the sensory-motor system.
The recognition of this peculiar EEG pattern could help the diagnostic work-up. Additionally, our findings supports the existence of a parallelism between this EEG trait and the physiological "mu" rhythm which is generate by the sensory-motor system. Such link suggests a sensory-motor system dysfunction in [r(20)] patients.
评估患有 20 号环状染色体 - [r(20)]-综合征患者的皮质节律的光谱和空间特征。
研究了 12 例 [r(20)] 综合征患者。作为对照，我们招募了 12 例特发性全面性癫痫（IGE）患者和 12 名健康志愿者（HV）。在所有病例中均应用盲源分离、频谱分析和源重建，以识别皮质活动的可靠时空模式。
在[r(20)]患者中发现了θ-δ EEG 节律，其频谱峰值在 3 到 7Hz 之间，其发生器映射在感觉运动皮质上。在 6 例中存在第二个峰值，其频率大约是第一个峰值的两倍。在 HV 和 IGE 组中类似的方法学方法未能显示出类似的发现。
[r(20)]患者的 EEG 显示出一种高度可重复的源自感觉运动系统的 EEG 模式的存在。
识别这种特殊的 EEG 模式可以帮助诊断。此外，我们的发现支持这种 EEG 特征与由感觉运动系统产生的生理“μ”节律之间存在平行关系。这种联系表明[r(20)]患者的感觉运动系统功能障碍。
