Benayoun Y, Rosenberg R, Casse G, Dallaudière B, Robert P-Y
Service d'ophtalmologie, hôpital Dupuytren, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex 1, France; Service d'ophtalmologie, clinique François-Chénieux, 18, rue du Général-Catroux, 87039 Limoges cedex, France.
J Fr Ophtalmol. 2013 Oct;36(8):693-703. doi: 10.1016/j.jfo.2013.04.006. Epub 2013 Aug 19.
Corneal neovascularization is defined as the invasion of vessels into the normally avascular clear corneal stroma, secondary to acute or chronic tissue injury. In addition to decreasing visual acuity, vascularity introduces circulating immune cells, reducing corneal immune privilege and the graft survival of subsequent keratoplasty. Thus, reducing neovascularization has become a recent therapeutic target in order to increase the success of corneal transplantation. Comparing the effects of antiangiogenic drugs assumes that we are able to quantify corneal neovascularization before and after treatment. In the first part of this literature review, we present the various methods to document neovessels (color photos, fluorescein and indocyanine green anterior segment angiography, in vivo confocal microscopy). Next, we report methods to classify and quantify corneal neovascularization.
角膜新生血管形成的定义是，继发于急性或慢性组织损伤后，血管侵入正常无血管的透明角膜基质。除了降低视力外，血管化还会引入循环免疫细胞，降低角膜免疫赦免以及后续角膜移植的移植物存活率。因此，为了提高角膜移植的成功率，减少新生血管形成已成为近期的治疗靶点。比较抗血管生成药物的效果，前提是我们能够在治疗前后对角膜新生血管形成进行量化。在这篇文献综述的第一部分，我们介绍了记录新生血管的各种方法（彩色照片、荧光素和吲哚菁绿眼前段血管造影、活体共聚焦显微镜检查）。接下来，我们报告角膜新生血管形成的分类和量化方法。
