Department of Psychology, The Ohio State University Newark, Newark, OH, USA.
Arch Clin Neuropsychol. 2014 Feb;29(1):100-9. doi: 10.1093/arclin/act065. Epub 2013 Aug 21.
Impairments in executive functioning are commonly found in Parkinson's disease (PD); however, the research into risky decision making has been mixed. The present study sought to investigate three potential hypotheses: difficulty learning the task probabilities, levodopa equivalent dose (LED), and the presence of apathy. Twenty-four individuals with idiopathic PD and 13 healthy controls completed the Frontal Systems Behavior Scale to assess current apathy, the Iowa Gambling Task, and the Balloon Analog Risk Task (BART). Results indicated that individuals with PD selected more from Deck B, a disadvantageous deck. However, with an additional set of trials, participants with PD and apathy selected more from the most risky deck (Deck A). Apathy was not related to the BART, and LED was not related to either task. Results indicate that apathy is associated with decision-making in PD, and providing additional learning trials can improve decision-making in PD without apathy.
执行功能障碍在帕金森病（PD）中很常见；然而，关于冒险决策的研究结果不一。本研究旨在调查三个潜在的假设：任务概率学习困难、左旋多巴等效剂量（LED）和冷漠的存在。24 名特发性 PD 患者和 13 名健康对照者完成了额叶系统行为量表，以评估当前的冷漠、爱荷华赌博任务和气球模拟风险任务（BART）。结果表明，PD 患者从不利的 B 组选择了更多的卡片。然而，通过额外的一组试验，PD 患者和伴有冷漠的患者从风险最高的 A 组选择了更多的卡片。冷漠与 BART 无关，LED 与两个任务都无关。结果表明，冷漠与 PD 患者的决策有关，提供额外的学习试验可以改善无冷漠的 PD 患者的决策能力。
