Neuroimaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands.
Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2571-86. doi: 10.1016/j.neubiorev.2013.08.004. Epub 2013 Aug 19.
Research using proton magnetic resonance spectroscopy (MRS) can potentially elucidate metabolite changes representing early degeneration in Mild Cognitive Impairment (MCI), an early stage of dementia. We integrated the published literature using meta-analysis to identify patterns of metabolite changes in MCI. 29 MRS studies (with a total of 607 MCI patients and 862 healthy controls) were classified according to brain regions. Hedges' g was used as effect size in a random effects model. N-Acetyl Aspartate (NAA) measures were consistently reduced in posterior cingulate (PC), hippocampus, and the paratrigonal white matter (PWM). Creatine (Cr) concentration was reduced in the hippocampus and PWM. Choline (Cho) concentration was reduced in the hippocampus while Cho/Cr ratio was raised in the PC. Myo-inositol (mI) concentration was raised in the PC and mI/Cr ratio was raised in the hippocampus. NAA/mI ratio was reduced in the PC. NAA may be the most reliable marker of brain dysfunction in MCI though mI, Cho, and Cr may also contribute towards this.
使用质子磁共振波谱（MRS）的研究可能能够阐明代表轻度认知障碍（MCI）早期退化的代谢物变化，MCI 是痴呆症的早期阶段。我们通过荟萃分析整合了已发表的文献，以确定 MCI 中代谢物变化的模式。根据脑区对 29 项 MRS 研究（共 607 名 MCI 患者和 862 名健康对照者）进行了分类。Hedges'g 用作随机效应模型中的效应量。在后扣带回（PC）、海马体和旁三角白质（PWM）中，N-乙酰天冬氨酸（NAA）测量值始终降低。在海马体和 PWM 中，肌酸（Cr）浓度降低。在海马体中胆碱（Cho）浓度降低，而 PC 中的 Cho/Cr 比值升高。在 PC 中肌醇（mI）浓度升高，而在海马体中 mI/Cr 比值升高。PC 中的 NAA/mI 比值降低。尽管 mI、Cho 和 Cr 也可能有助于这一点，但 NAA 可能是 MCI 中脑功能障碍最可靠的标志物。
