Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Epilepsy Behav. 2013 Oct;29(1):144-9. doi: 10.1016/j.yebeh.2013.07.004. Epub 2013 Aug 20.
Our study aimed to investigate whether the glutamatergic system in the hippocampus is correlated with depressive symptoms in patients with epilepsy.
Fifty patients with epilepsy were recruited and divided into three groups on the basis of their Hamilton Depression Rating Scale (HAMD) scores. Single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) was carried out. Pearson correlation analysis and multiple linear regression analysis were performed to investigate any correlation between the variables of hippocampal metabolites and HAMD scores.
Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores. Multiple linear regression analysis showed that the ratio of Glx/Cr in the right hippocampus was an independent risk factor relating to depressive symptoms in patients with epilepsy.
A disturbance of the hippocampal glutamatergic system may be involved in the pathogenesis of depression in epilepsy.
本研究旨在探讨海马体中的谷氨酸能系统是否与癫痫患者的抑郁症状相关。
招募了 50 名癫痫患者，并根据其汉密尔顿抑郁量表（HAMD）评分将其分为三组。进行单质子磁共振波谱（1H-MRS）检查。采用 Pearson 相关分析和多元线性回归分析，探讨海马代谢物变量与 HAMD 评分之间的相关性。
质子磁共振波谱分析显示，中度抑郁患者右侧海马体谷氨酸/谷氨酰胺与肌酸的比值（Glx/Cr）显著升高，且与 HAMD 评分呈正相关。多元线性回归分析显示，右侧海马体 Glx/Cr 比值是与癫痫患者抑郁症状相关的独立危险因素。
海马体谷氨酸能系统的紊乱可能与癫痫相关的抑郁发病机制有关。
