Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France.
J Occup Environ Med. 2013 Sep;55(9):1065-73. doi: 10.1097/JOM.0b013e318298fae4.
To investigate the associations between occupations and head and neck (HN) cancer risk in men.
ICARE is a French population-based case-control study on HN cancer. Analyses included 1833 cases and 2747 controls. Complete occupational history was collected. Odds ratios (ORs) were estimated for occupations and industries ever held and according to duration of employment.
Elevated ORs, increasing with duration of employment, were observed for several occupations, including cleaners (OR = 1.7; 95% confidence interval [CI], 1.0 to 2.8), launderers (OR = 6.8; CI, 1.3 to 34.4), firefighters (OR = 3.9; CI, 1.4 to 11.2), several agricultural occupations, welders (OR = 1.9; CI, 1.3 to 2.8), structural metal preparers and erectors (OR = 2.1; CI, 1.2 to 3.7), rubber workers (OR = 2.0; CI, 1.0 to 3.9), several construction occupations, and material-handling equipment operators (OR = 1.8; CI, 1.1 to 2.9). Analyses by industry corroborated these findings.
These results confirmed the role of occupational exposures in HN cancer.
探讨男性职业与头颈部（HN）癌症风险之间的关联。
ICARE 是一项针对 HN 癌症的法国基于人群的病例对照研究。分析包括 1833 例病例和 2747 例对照。收集了完整的职业史。根据职业和就业时间的长短，计算了比值比（OR）。
观察到几种职业的 OR 值升高，且随就业时间的延长而增加，包括清洁工（OR = 1.7；95%置信区间 [CI]，1.0 至 2.8）、洗衣工（OR = 6.8；CI，1.3 至 34.4）、消防员（OR = 3.9；CI，1.4 至 11.2）、一些农业职业、焊工（OR = 1.9；CI，1.3 至 2.8）、结构金属准备工和安装工（OR = 2.1；CI，1.2 至 3.7）、橡胶工人（OR = 2.0；CI，1.0 至 3.9）、一些建筑职业和物料搬运设备操作员（OR = 1.8；CI，1.1 至 2.9）。按行业分析证实了这些发现。
这些结果证实了职业暴露对头颈部癌症的作用。
