Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Int J Oncol. 2013 Nov;43(5):1343-50. doi: 10.3892/ijo.2013.2075. Epub 2013 Aug 22.
G-protein coupled receptors (GPCRs) represent the most diverse and biologically ubiquitous protein receptors. The epidermal growth factor seven-span transmembrane (EGF-TM7) family consists of adhesion GPCRs with a diverse functional repertoire. CD97 is the most broadly expressed member with roles in cell adhesion, migration and regulation of intercellular junctions. CD97 is also expressed in a variety of human malignancies including those of the thyroid, stomach, colon and brain. CD97 confers an invasive phenotype and has been shown to correlate with tumor grade, lymph node invasion, metastatic spread and overall prognosis. More recently, CD97 was found to signal through Gα12/13, resulting in increased RHO-GTP levels. Proven roles in tumor invasion and signaling make CD97 an exciting novel therapeutic target. In this review, we will discuss the structure and function of this receptor, with a specific focus on its mechanistic significance in neoplastic diseases.
G 蛋白偶联受体（GPCRs）是最多样化和最普遍存在的生物蛋白受体。表皮生长因子七跨膜（EGF-TM7）家族由具有不同功能谱的粘附 GPCR 组成。CD97 是表达最广泛的成员，其在细胞黏附、迁移和细胞间连接的调节中发挥作用。CD97 也在多种人类恶性肿瘤中表达，包括甲状腺、胃、结肠和脑肿瘤。CD97 赋予侵袭表型，并已被证明与肿瘤分级、淋巴结侵犯、转移扩散和总体预后相关。最近发现 CD97 通过 Gα12/13 信号传导，导致 RHO-GTP 水平升高。在肿瘤侵袭和信号转导方面的作用已被证实，使 CD97 成为一个令人兴奋的新型治疗靶点。在这篇综述中，我们将讨论该受体的结构和功能，特别关注其在肿瘤疾病中的机制意义。
