Quality-Control Analytical Methods: Minimizing the Probability of Out-of-Specification Preparations: Results That Make You Say...Hmmm!

To prevent compounding of an out-of-specification preparation, the possible causes of such an error must be identified and eliminated. Implementation of simple practices can decrease the probability of errors, resulting in a safer situation for both the patient and the pharmacy. The United States Pharmacopeia-National Formulary is the standard-setting reference for compounding procedures; all compounding pharmacists should read and adhere to those standards. This article discusses these standards as they relate to drug potency, sterility, endotoxin, and particulate matter results.