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Reply: Comment on 'Beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'--β-blockers are potent anti-angiogenic and chemo-sensitising agents, rather than cytotoxic drugs.回复：关于“β受体阻滞剂通过直接抗肿瘤和抗血管生成机制增强神经母细胞瘤对化疗的反应”的评论——β受体阻滞剂是有效的抗血管生成和化疗增敏剂，而非细胞毒性药物。
Br J Cancer. 2013 Oct 1;109(7):2024-5. doi: 10.1038/bjc.2013.498. Epub 2013 Aug 22.
2
Comment on 'Beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'.关于“β受体阻滞剂通过直接抗肿瘤和抗血管生成机制增强神经母细胞瘤对化疗的反应”的评论
Br J Cancer. 2013 Oct 1;109(7):2022-3. doi: 10.1038/bjc.2013.497. Epub 2013 Aug 22.
3
β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma.β 受体阻滞剂通过直接的抗肿瘤和抗血管生成机制增加神经母细胞瘤对化疗的反应。
Br J Cancer. 2013 Jun 25;108(12):2485-94. doi: 10.1038/bjc.2013.205. Epub 2013 May 21.
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Anti-angiogenesis in neuroblastoma.神经母细胞瘤的抗血管生成治疗。
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'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.“意外的”抗血管生成药物。以抗癌基因导向的信号转导抑制剂和传统化疗药物为例。
Eur J Cancer. 2000 Jun;36(10):1248-57. doi: 10.1016/s0959-8049(00)00092-7.
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Kurume Med J. 1984;31(1):1-6. doi: 10.2739/kurumemedj.31.1.
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[Observation of regression of generalized neuroblastoma in a child].[一名儿童广泛性神经母细胞瘤消退的观察]
Klin Khir. 2002 Oct(10):57-8.
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Interferon-mediated anti-angiogenic therapy for neuroblastoma.干扰素介导的神经母细胞瘤抗血管生成治疗
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Radical surgery for abdominal neuroblastoma.腹部神经母细胞瘤的根治性手术
Semin Surg Oncol. 1993 Nov-Dec;9(6):489-92. doi: 10.1002/ssu.2980090606.
10
Angiogenesis as a target in neuroblastoma.血管生成作为神经母细胞瘤的一个靶点。
Eur J Cancer. 2008 Aug;44(12):1645-56. doi: 10.1016/j.ejca.2008.05.015. Epub 2008 Jul 7.

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MicroRNAs and cancer: Key paradigms in molecular therapy.微小RNA与癌症：分子治疗的关键范例
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本文引用的文献

1
Comment on 'Beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'.关于“β受体阻滞剂通过直接抗肿瘤和抗血管生成机制增强神经母细胞瘤对化疗的反应”的评论
Br J Cancer. 2013 Oct 1;109(7):2022-3. doi: 10.1038/bjc.2013.497. Epub 2013 Aug 22.
2
β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma.β 受体阻滞剂通过直接的抗肿瘤和抗血管生成机制增加神经母细胞瘤对化疗的反应。
Br J Cancer. 2013 Jun 25;108(12):2485-94. doi: 10.1038/bjc.2013.205. Epub 2013 May 21.
3
Has the time come for metronomics in low-income and middle-income countries?在中低收入国家，采用节拍化疗的时机是否已经成熟？
Lancet Oncol. 2013 May;14(6):e239-48. doi: 10.1016/S1470-2045(13)70056-1.
4
Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy.在接受根治性放疗的非小细胞肺癌患者中，偶然使用β受体阻滞剂可改善生存结局。
Ann Oncol. 2013 May;24(5):1312-9. doi: 10.1093/annonc/mds616. Epub 2013 Jan 8.
5
Impact of beta blockers on epithelial ovarian cancer survival.β受体阻滞剂对上皮性卵巢癌生存的影响。
Gynecol Oncol. 2012 Nov;127(2):375-8. doi: 10.1016/j.ygyno.2012.07.102. Epub 2012 Jul 20.
6
Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children's Oncology Group study P9641.低风险神经母细胞瘤患者单纯手术或限制化疗的治疗效果：儿童肿瘤协作组研究 P9641 的结果。
J Clin Oncol. 2012 May 20;30(15):1842-8. doi: 10.1200/JCO.2011.37.9990. Epub 2012 Apr 23.
7
Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment.普萘洛尔增强化疗药物的抗血管生成作用和抗肿瘤疗效：对乳腺癌治疗的意义。
Oncotarget. 2011 Oct;2(10):797-809. doi: 10.18632/oncotarget.343.
8
β-Blockers and survival among Danish patients with malignant melanoma: a population-based cohort study.β 受体阻滞剂与丹麦恶性黑色素瘤患者生存：一项基于人群的队列研究。
Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2273-9. doi: 10.1158/1055-9965.EPI-11-0249. Epub 2011 Sep 20.
9
Beta blockers and breast cancer mortality: a population- based study.β受体阻滞剂与乳腺癌死亡率：一项基于人群的研究。
J Clin Oncol. 2011 Jul 1;29(19):2635-44. doi: 10.1200/JCO.2010.33.5422. Epub 2011 May 31.
10
Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer.β受体阻滞剂的使用与三阴性乳腺癌患者无复发生存率的改善相关。
J Clin Oncol. 2011 Jul 1;29(19):2645-52. doi: 10.1200/JCO.2010.33.4441. Epub 2011 May 31.

Reply: Comment on 'Beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'--β-blockers are potent anti-angiogenic and chemo-sensitising agents, rather than cytotoxic drugs.

作者信息

Pasquier E, Andre N, Trahair T, Kavallaris M

机构信息

1] Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW 2031, Australia [2] Metronomics Global Health Initiative, Marseille 13005, France.

出版信息

Br J Cancer. 2013 Oct 1;109(7):2024-5. doi: 10.1038/bjc.2013.498. Epub 2013 Aug 22.

DOI:10.1038/bjc.2013.498
PMID:23969728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3790159/
Abstract
摘要