有效的预防策略可防止化疗期间出现手掌-足底红斑感觉异常。
Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy.
机构信息
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
出版信息
Skin Pharmacol Physiol. 2014;27(2):66-70. doi: 10.1159/000351801. Epub 2013 Aug 21.
BACKGROUND
Pegylated liposomal doxorubicin (PLD) is a highly efficient chemotherapeutic; however, it induces dermal side effects such as palmar-plantar erythrodysesthesia (PPE) in up to 80% of cases, probably by being emitted with the sweat onto the skin surface.
AIM
The aim of the present study was to examine whether a topically applied ointment containing antioxidants with a high radical protection factor is able to prevent the formation of PPE.
METHODS
Twenty patients suffering from ovarian carcinoma and treated with PLD were observed.
RESULTS
60% of the patients tolerated the regular application of the cream and developed no PPE. The remaining 40% interrupted the application. Six of them developed PPE and resumed ointment application thereafter. In these cases the PPE disappeared or was strongly reduced.
CONCLUSION
The results of the observation clearly demonstrate that topical application of the ointment is an efficient strategy against the development of PPE during chemotherapy with PLD.
背景
聚乙二醇化脂质体阿霉素（PLD）是一种高效的化疗药物；然而，它会引起皮肤副作用，如掌跖红细胞感觉异常（PPE），在多达 80%的病例中，这可能是由于它与汗液一起排放到皮肤表面。
目的
本研究旨在探讨一种含有高自由基保护因子的抗氧化剂的局部应用软膏是否能够预防 PPE 的形成。
方法
观察了 20 例患有卵巢癌并接受 PLD 治疗的患者。
结果
60%的患者耐受了常规应用乳膏，未出现 PPE。其余 40%的患者中断了应用。其中 6 人出现 PPE，此后恢复了软膏应用。在这些情况下，PPE 消失或明显减少。
结论
观察结果清楚地表明，在 PLD 化疗期间，局部应用软膏是预防 PPE 发展的有效策略。
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