Hanakawa Hiroyuki, Orita Yorihisa, Sato Yasuharu, Uno Kinya, Nishizaki Kazunori, Yoshino Tadashi
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Acta Med Okayama. 2013;67(4):265-9. doi: 10.18926/AMO/51072.
We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.
我们报告一例67岁的日本男性，其患有严重的口咽溃疡，起初看似是侵袭性恶性淋巴瘤或口咽癌。我们怀疑这是由甲氨蝶呤（MTX）治疗类风湿关节炎（RA）引发的与MTX相关的淋巴增殖性疾病（LPD）。单纯停用MTX约3周后，观察到病情完全缓解，从而证实了我们的诊断。
