Molecular Imaging Program NCI Building 10 Room B3B69F Bethesda, MD 20892, USA.
Radiology. 2013 Sep;268(3):617-8. doi: 10.1148/radiol.13131447.
The era of stromal-based therapies is coming, and methods to image the stroma are likely to become vital to improved understanding of the intricate interrelationships of these cells. Because fibroblasts are so important for the initiation of cancer, stromal-based therapies may serve as preventive regimens in patients who are at high risk for recurrent disease. The method described by Vandsburger et al uses a reporter-gene magnetic resonance (MR) imaging–agent paradigm that withstands dilution from cell division while allowing imaging without ionizing radiation. The requirement for gene transfection makes near-term clinical translation unlikely, but the opportunities for studying cancer-associated fibroblast activity in tumor models and observing and modulating their migratory behavior is an exciting prospect, one that is hoped to bring tangible benefits to patients with cancer.
基质疗法的时代即将到来，而对基质进行成像的方法可能对于更好地理解这些细胞之间复杂的相互关系变得至关重要。由于成纤维细胞对于癌症的发生如此重要，基质为基础的治疗方法可能作为预防方案，适用于那些有复发性疾病高风险的患者。Vandsburger 等人描述的方法使用报告基因磁共振（MR）成像剂范例，该范例可耐受细胞分裂的稀释，同时允许在不使用电离辐射的情况下进行成像。基因转染的要求使得近期的临床转化不太可能，但在肿瘤模型中研究与癌症相关的成纤维细胞活性并观察和调节其迁移行为的机会是一个令人兴奋的前景，有望为癌症患者带来切实的益处。
