Outside the Black Box: Re-assessing Pediatric Antidepressant Prescription.
作者信息
Sparks Jacqueline A, Duncan Barry L
机构信息
University of Rhode Island, Kingston, Rhode Island, USA.
出版信息
J Can Acad Child Adolesc Psychiatry. 2013 Aug;22(3):240-6.
Abstract
OBJECTIVE
The purpose of this review is to assess whether evidence supports a favorable risk/benefit profile for pediatric antidepressant use and reconsideration of the black box.
METHOD
The review examines studies post-black box purporting to show declines in pediatric antidepressant use and rising youth suicide, summarizes evidence for efficacy and safety of pediatric antidepressants, and discusses irregularities in recent meta-analyses of fluoxetine for youth.
RESULTS
Pediatric antidepressant prescription did not significantly decline post-black box and youth suicide has risen only in recent years. Recent meta-analyses fail to undermine evidence that antidepressants are associated with increased risk of suicidality in youth.
CONCLUSIONS
First line prescription of antidepressants for youth is not advisable. The black box and international warnings on pediatric use of antidepressants are warranted. Wider availability of psychosocial options for depressed youth is recommended.
摘要
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