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颅内动脉夹层的血管内治疗:临床及血管造影随访

Endovascular treatment of intracranial artery dissection: clinical and angiographic follow-up.

作者信息

Mohammadian Reza, Taheraghdam Ali Akbar, Sharifipour Ehsan, Mansourizadeh Reza, Pashapour Ali, Shimia Mohammad, Shokouhi Ghaffar, Shakeri Moslem, Hashemzadeh Ali

机构信息

Neuroscience Research Center, Tabriz University of Medical Sciences, P.O. Box 51665-348, Tabriz, Iran.

出版信息

Neurol Res Int. 2013;2013:968380. doi: 10.1155/2013/968380. Epub 2013 Jul 22.

Abstract

Background. Intracranial artery dissections are rare and many controversies exist about treatment options. The aim of this study was to evaluate the efficacy and safety of the endovascular approach in patients with an intracranial dissection presenting with different symptoms. Methods. We prospectively evaluated the clinical features and treatment outcomes of 30 patients who had angiographically confirmed nontraumatic intracranial dissections over 4 years. Patients were followed up for 17 months, and their final outcomes were assessed by the modified Rankin Score (mRS) and angiography. Results. Sixteen (53.3%) patients had a dissection of the anterior circulation, whereas 14 (46.7%) had a posterior circulation dissection. Overall, 83.3% of the patients suffered a subarachnoid hemorrhage (SAH). Grade IV Hunt and Hess score was seen in 32% of the SAH presenting cases. Parent artery occlusion (PAO) with coil embolization was used in 70% of the cases. The prevalence of overall procedural complications was 23.3%, and all were completely resolved at the end of follow-up. No evidence of in-stent occlusion/stenosis or rebleeding was observed in our cases during follow-up. Angiography results improved more frequently in the PAO with coil embolization group (100%) than in the stent-only-treated group (88.9%) (P = 0.310) and the unruptured dissection group (5/5, 100%) in comparison with the group that presented with SAH (95.8%) (P = 0.833). Conclusion. Favorable outcomes were achieved following an endovascular approach for symptomatic ruptured or unruptured dissecting aneurysms. However, the long-term efficacy and durability of these procedures remain to be determined in a larger series.

摘要

背景。颅内动脉夹层很少见,关于治疗方案存在诸多争议。本研究的目的是评估血管内治疗方法对表现出不同症状的颅内动脉夹层患者的疗效和安全性。方法。我们前瞻性评估了30例经血管造影证实为非创伤性颅内动脉夹层的患者在4年中的临床特征和治疗结果。对患者进行了17个月的随访,并通过改良Rankin量表(mRS)和血管造影评估其最终结果。结果。16例(53.3%)患者出现前循环夹层,而14例(46.7%)出现后循环夹层。总体而言,83.3%的患者发生了蛛网膜下腔出血(SAH)。32%的SAH病例出现IV级Hunt和Hess评分。70%的病例采用了带弹簧圈栓塞的母动脉闭塞术(PAO)。总体手术并发症发生率为23.3%,所有并发症在随访结束时均完全缓解。在我们的病例随访期间,未观察到支架内闭塞/狭窄或再出血的证据。与单纯支架治疗组(88.9%)相比,带弹簧圈栓塞的PAO组血管造影结果改善更频繁(100%)(P = 0.310),与出现SAH的组(95.8%)相比,未破裂夹层组(5/5,100%)血管造影结果改善更频繁(P = 0.833)。结论。对于有症状的破裂或未破裂夹层动脉瘤,血管内治疗方法取得了良好的结果。然而,这些手术的长期疗效和持久性仍有待在更大规模的系列研究中确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3b2/3736402/a1546e012b62/NRI2013-968380.001.jpg

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