拟交感神经胺能有效控制对其他疗法无反应的间质性膀胱炎的疼痛。
Sympathomimetic amines effectively control pain for interstitial cystitis that had not responded to other therapies.
作者信息
Check J H, Cohen G, Cohen R, Dipietro J, Steinberg B
机构信息
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, New Jersey, USA.
出版信息
Clin Exp Obstet Gynecol. 2013;40(2):227-8.
PURPOSE
To further investigate the efficacy of treatment of interstitial cystitis that had been refractory to standard treatment with sympathomimetic amines.
METHODS
Dextroamphetamine sulfate sustained release capsules up to 30 mg per day were prescribed in women with refractory painful bladder syndrome/interstitial cystitis in six new cases. The patients were carefully evaluated for relief of symptoms.
RESULTS
All six women found marked relief in their painful bladder syndrome in a rather short length of time. The benefit persisted as long as the therapy was maintained. Temporary cessation resulted in prompt return of symptoms, but resumption of sympathomimetic amines again allowed good relief of bladder pain and related symptoms.
CONCLUSIONS
Because of very few side-effects and no drug dependence in the dosage used, sympathomimetic amines should be considered for first-line therapy.
目的
进一步研究对标准拟交感神经胺治疗无效的间质性膀胱炎的治疗效果。
方法
为6例难治性膀胱疼痛综合征/间质性膀胱炎的女性患者开具每日剂量高达30毫克的硫酸右苯丙胺缓释胶囊。对患者的症状缓解情况进行仔细评估。
结果
所有6名女性在相当短的时间内膀胱疼痛综合征都有明显缓解。只要维持治疗，益处就会持续。暂时停药会导致症状迅速复发，但重新使用拟交感神经胺可再次有效缓解膀胱疼痛及相关症状。
结论
由于所用剂量副作用极少且无药物依赖性，拟交感神经胺应被视为一线治疗药物。
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