手术广泛切除联合羊膜移植并辅助局部应用丝裂霉素C治疗复发性结膜-角膜上皮内瘤的效果
The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin C treatment in recurrent conjunctival--corneal intraepithelial neoplasia.
作者信息
Lee Jae Hyung, Kim Yeong Hoon, Kim Man Soo, Kim Eun Chul
机构信息
Department of Ophthalmology & Visual Science, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
出版信息
Semin Ophthalmol. 2014 Jul;29(4):192-5. doi: 10.3109/08820538.2013.810280. Epub 2013 Aug 23.
PURPOSE
To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04% eye drops on recurrent conjunctival-corneal intraepithelial neoplasia (CCIN).
METHODS
The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival-corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year.
RESULTS
Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months.
CONCLUSIONS
Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.
目的
探讨手术广泛切除联合0.04%丝裂霉素C滴眼液辅助羊膜移植治疗复发性结膜角膜上皮内瘤（CCIN）的效果。
方法
作者对一名复发性结膜角膜上皮内瘤患者在肿瘤完全手术切除后应用羊膜移植。肿瘤同时存在结膜病变和角膜混浊。一周后，患者每天四次使用0.04%丝裂霉素C滴眼液，持续一个月以预防复发。在裂隙灯显微镜下评估眼部并发症和复发情况，为期一年。
结果
术后一周内角膜上皮完全愈合。结膜和角膜病变均完全消退，随访24个月未发现复发。
结论
手术广泛切除联合局部应用丝裂霉素C辅助羊膜移植将是治疗复发性CCIN的一种有效治疗方式。
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