Sanders Francis W B, Huang Jinhai, Alió Del Barrio Jorge L, Hamada Samer, McAlinden Colm
Department of Ophthalmology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK.
Eye and ENT Hospital, Fudan University, Shanghai, China.
Eye (Lond). 2024 Mar;38(4):668-679. doi: 10.1038/s41433-023-02777-5. Epub 2023 Oct 24.
The amniotic membrane is a single epithelial layer of the placenta. It has anti-inflammatory, anti-scarring, anti-angiogenic and possibly bactericidal properties. The basement membrane of the amniotic membrane acts as a substrate to encourage healing and re-epithelialisation. It has been used in many ocular surface diseases including persistent epithelial defects (corneal or conjunctival), chemical or thermal burns, limbal stem cell deficiency, cicatrising conjunctivitis, ocular graft versus host disease, microbial keratitis, corneal perforation, bullous keratopathy, dry eye disease, corneal haze following refractive surgery and cross-linking, band keratopathy, ocular surface neoplasia, pterygium surgery, and ligneous conjunctivitis. This review provides an up-to-date overview of amniotic membrane transplantation including the structural and biological properties, preparation and application, clinical indications, and commercially available products.
羊膜是胎盘的单层上皮。它具有抗炎、抗瘢痕、抗血管生成以及可能的杀菌特性。羊膜的基底膜作为促进愈合和再上皮化的基质。它已被用于多种眼表疾病，包括持续性上皮缺损（角膜或结膜）、化学或热烧伤、角膜缘干细胞缺乏、瘢痕性结膜炎、眼移植物抗宿主病、微生物性角膜炎、角膜穿孔、大泡性角膜病变、干眼疾病、屈光手术和交联术后的角膜混浊、带状角膜病变、眼表肿瘤、翼状胬肉手术以及木质素性结膜炎。本综述提供了羊膜移植的最新概述，包括其结构和生物学特性、制备和应用、临床适应症以及市售产品。
