南海柳珊瑚 Ellisella dollfusi 中新型半日花烷型二萜。

New briarane-type diterpenoids from gorgonian Ellisella dollfusi from the South China Sea.

机构信息

a Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy , Ocean University of China , Qingdao , 266003 , P.R. China.

出版信息

Nat Prod Res. 2014;28(1):7-11. doi: 10.1080/14786419.2013.827191. Epub 2013 Aug 25.

DOI:10.1080/14786419.2013.827191

PMID:23972040

Abstract

Two new briarane-type diterpenoids, dollfusilin A (1) and dollfusilin B (2), along with five known briarane-type diterpenoids (3-7), were isolated from the gorgonian Ellisella dollfusi collected from the South China Sea. The structures of the two new compounds (1 and 2) were elucidated through a comprehensive analysis of spectroscopic data, especially 2D NMR. The bioactivities of the isolated compounds were evaluated using the zebrafish toxicity model.

摘要

从南海采集的柳珊瑚 Ellisella dollfusi 中分离得到了两个新的柳珊瑚型二萜 dollfusilin A（1）和 dollfusilin B（2），以及五个已知的柳珊瑚型二萜（3-7）。通过对光谱数据，特别是 2D NMR 的综合分析，阐明了两个新化合物（1 和 2）的结构。采用斑马鱼毒性模型评价了分离得到的化合物的生物活性。