[氨酰-tRNA合成酶在心肌缺血时兔肝脏蛋白质生物合成速率变化中的作用]
[Role of aminoacyl-tRNA-synthetases in changes in the rate of protein biosynthesis in the rabbit liver during myocardial ischemia].
作者信息
Martinkus Z P, Ivanov L L, Lekis A V, Priashkiavichius A K
出版信息
Biull Eksp Biol Med. 1990 Jun;109(6):563-5.
PMID:2397292
Abstract
Composition of high-molecular-weight aminoacyl-tRNA synthetases complexes from rabbit liver both in norm and after 12 h experimental myocardial ischemia (EMI) has been investigated. Partial redistribution of aminoacyl-tRNA synthetases activity from 1820 kD complex into 840 kD complex was observed in case of EMI which resulted in changes of protein biosynthesis rate in cell-free system.
摘要
对正常及实验性心肌缺血（EMI）12小时后兔肝脏高分子量氨酰-tRNA合成酶复合物的组成进行了研究。在EMI情况下，观察到氨酰-tRNA合成酶活性从1820 kD复合物部分重新分布到840 kD复合物中，这导致了无细胞系统中蛋白质生物合成速率的变化。
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